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. 2021 Dec 13;8:761841. doi: 10.3389/fmolb.2021.761841

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Copyright © 2021 Hu, Zhang, Li, Liu, Ao, Li, Zeng and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of knockdown and overexpressed ATF3 on cell viability, apoptosis, and cell cycle in rheumatoid arthritis fibroblast-like synoviocyte (RA-FLS) and MH7A. (A) The results of Cell Counting Kit-8 (CCK-8) assay revealed that the cell viability in the Sh-ATF3 group was lower than in Sh-Ctrl group, and those in the ATF-OE group were higher than in the Ctrl-OE group (mean ± SD, n = 3). (B) Flow cytometry was performed to analyze cell apoptosis. The typical image of apoptosis in RA-FLS and MH7A. (C) The results of apoptosis rate showed that Sh-ATF3 induced apoptosis in RA-FLS and MH7A, while ATF3-OE inhibited apoptosis in them (mean ± SD, n = 3). (D) Flow cytometry was performed to analyze cell cycle. The typical image of cell cycle in RA-FLS and MH7A. t-Test was performed to analyze the statistical difference. ** p < 0.01, *** p < 0.001.