Table 5.

Welch's t-test statistic (p-value/Cohen's d) values for different subcortical ROIs from the Harvard-Oxford atlas.

Subcortical ROI name	AD vs. HC left	pMCI vs. sMCI left	AD vs. HC right	pMCI vs. sMCI right
Brain stem	−159.23 (<0.001/1.82)	−111.17 (<0.001/0.53)	−	−
Amygdala	−89.70 (<0.001/4.41)	−83.48 (<0.001/1.43)	−74.61 (<0.001/4.00)	−66.36 (<0.001/1.57)
Caudate	−97.02 (<0.001/4.69)	−98.82 (<0.001/1.69)	−101.28 (<0.001/4.41)	−102.43 (<0.001/1.47)
Cerebral cortex	−576.47 (<0.001/1.98)	−539.03 (<0.001/0.81)	−562.68 (<0.001/1.93)	−528.37 (<0.001/0.89)
Cerebral WM	−1083.13 (<0.001/5.29)	−857.54 (<0.001/2.48)	−1018.97 (<0.001/4.32)	−867.04 (<0.001/2.56)
Hippocampus	−145.32 (<0.001/4.95)	−131.04 (<0.001/1.72)	−146.84 (<0.001/5.77)	−139.80 (<0.001/2.65)
Lateral ventricle	−9.77 (<0.001/0.30)	−9.67 (<0.001/0.11)	−8.57 (<0.001/0.27)	−8.37 (<0.001/0.09)
Pallidum	−191.76 (<0.001/11.80)	−314.02 (<0.001/5.91)	−215.40 (<0.001/13.31)	−175.65 (<0.001/8.31)
Putamen	−562.54 (<0.001/15.59)	−382.47 (<0.001/6.82)	−427.50 (<0.001/10.66)	−306.99 (<0.001/5.13)
Thalamus	−148.15 (<0.001/4.02)	−148.75 (<0.001/1.60)	−165.48 (<0.001/4.80)	−162.59 (<0.001/2.11)
Accumbens	−461.68 (<0.001/30.02)	−205.64 (<0.001/9.60)	−472.20 (<0.001/31.00)	−209.78 (<0.001/9.80)

For Cohen's d, higher values indicate a positive effect size for the first disease group specified.