Table 4.

The Prognostic Factors Relevant to the CSS of SCLC Patients with BM (n=1717)

Characteristics	Univariate Cox		Multivariate Cox
	HR(95% CI)	P-value	HR(95% CI)	P-value
Age (years)	1.025(1.02–1.031)	<0.001	1.016(1.01–1.022)	<0.001
Sex
Male	Reference		Reference
Female	0.948(0.858–1.048)	0.296	0.958(0.866–1.06)	0.403
Race
White	Reference		Reference
Black	0.982(0.842–1.145)	0.815	0.873(0.747–1.02)	0.087
Others	0.802(0.624–1.031)	0.085	0.611(0.474–0.789)	<0.001
Tumor size (mm)
<28	Reference		Reference
28–45	1.135(0.981–1.315)	0.09	1.16(0.967–1.392)	0.11
>45	1.225(1.082–1.387)	0.001	1.292(1.095–1.523)	0.002
T Stage
T1	Reference		Reference
T2	1.054(0.895–1.241)	0.532	0.989(0.8–1.223)	0.92
T3	1.148(0.966–1.363)	0.117	1.01(0.82–1.245)	0.923
T4	1.185(1.012–1.388)	0.035	1.01(0.822–1.241)	0.923
N Stage
N0	Reference		Reference
N1	0.99(0.806–1.218)	0.927	1.087(0.883–1.338)	0.431
N2	1.306(1.142–1.493)	<0.001	1.56(1.36–1.788)	<0.001
N3	1.275(1.083–1.501)	0.004	1.504(1.273–1.777)	<0.001
Surgery
No	Reference		Reference
Yes	0.442(0.281–0.695)	<0.001	0.596(0.375–0.945)	0.028
Radiotherapy
No	Reference		Reference
Adjuvant	0.718(0.634–0.812)	<0.001	0.848(0.746–0.963)	0.011
Neo-adjuvant	1.105(0.593–2.06)	0.752	1.183(0.632–2.217)	0.599
Chemotherapy
No	Reference		Reference
Yes	0.271(0.242–0.305)	<0.001	0.267(0.236–0.302)	<0.001

Abbreviations: HR, hazard ratio; CI: confidence interval.