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. 2021 Dec 17;25(2):59. doi: 10.3892/mmr.2021.12575

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Inhibition of RANKL-induced osteoclast formation and bone resorption in RAW264.7 cells by ZOL. Images showing (A) TRAP staining and (B) bone resorption pits (indicated by white arrows). Scale bars: (A) 200 µm and (B) 500 µm. (C) RANKL-induced formation of TRAP+ multinucleated osteoclasts. (D) Determination of number of resorption pits. ##P<0.01 vs. vehicle group and **P<0.01 vs. RANKL-only group. ZOL, zoledronic acid; TRAP, tartrate-resistant acid phosphatase; M-CSF, macrophage colony-stimulating factor; RANKL, receptor activator of nuclear factor-κB ligand.