Table 3.
Adverse events in sepsis intubations, stratified by induction agent. Only sepsis cases (n=531) are reported in this table.
| Outcome | Induction agent | ||||
|---|---|---|---|---|---|
| Etomidate (n=363) | Ketamine (n=140) |
Midazolam (n=2) |
Propofol (n=8) |
No meds (n=17) |
|
| First-Pass Intubation Success, n (%) | 322 (88.7) | 118 (84.3) | 1 (50.0) | 8 (100.0) | 14 (82.4) |
| Peri-Intubation Adverse Events, n (%) | 81 (15.8) | 38 (27.1) | 1 (50.0) | 1 (12.5) | 1 (5.9) |
| Oxygen Desaturation (SpO2<90%), n (%) | 41 (11.3) | 16 (11.4) | 2 (100.0) | 1 (12.5) | 1 (5.9) |
| Hypotension (SBP < 100 mmHg) within 15 minutes after medications, n (%) | 182 (49.5) | 100 (74.1) | 1 (50.0) | 1 (12.5) | 3 (17.6) |
| Lowest SBP (mmHg), median (IQR) | 72 (60–84) | 74.5 (65–84) | 95 (95–95) | 70 (70–70) | 60 (53–70) |
| Medications given within 15 minutes after induction | |||||
| Any treatment for hypotension, n (%) | 136 (37.5) | 76 (54.3) | 2 (100.0) | 1 (12.5) | 3 (17.6) |
| Vasopressor, n (%) | 85 (23.4) | 42 (30.0) | 2 (100.0) | 0 (0.0) | 5 (29.4) |
| Any sedation (including propofol, ketamine, morphine, midazolam, diazepam, fentanyl, etomidate, or morphine) n (%) | 274 (75.5) | 105 (75.0) | 2 (100.0) | 6 (75.0) | 9 (52.9) |
| Peri-Intubation adverse events OR post-intubation hypotension (<100mmHg), n (%) | 82 (22.6) | 41 (29.3) | 2 (100.0) | 1 (12.5) | 1 (5.9) |