TABLE 1.
Qualitative expression of Ar mRNA distribution by nuclei in postnatal and adult mouse brain
| Brain areas and nuclei | Adult | Prepubertal | ||||
|---|---|---|---|---|---|---|
| PND 56–70 | PND 12 | PND 21 | ||||
| Male | Female | Male | Female | Male | Female | |
| Cerebral cortex | ||||||
| Motor (MO) | +/− | +/− | +/− | +/− | +/− | +/− |
| Olfactory nucleus, anterior (AON) | − | − | ++ | ++ | ++ | ++ |
| Taenia tecta (TT) | + | +/− | + | + | + | + |
| Piriform (PIR) | + | + | + | + | + | + |
| Cingulate, anterior (ACA) | + | + | + | + | + | + |
| Endopiriform (EP) | +/− | +/− | +/− | +/− | + | +/− |
| Hippocampal formation | ||||||
| Induseum griseum (IG) | + | + | + | + | + | + |
| Field CA1 (CA1) | +++ | +++ | +++ | +++ | +++ | +++ |
| Field CA2 (CA2) | +++ | +++ | +++ | +++ | +++ | +++ |
| Field CA3 (CA3) | + | + | + | + | + | + |
| Dentate gyrus (DG) | + | + | +/− | +/− | + | + |
| Entorhinal area (ENT) | +/− | +/− | + | + | +/− | +/− |
| Presubiculum/subiculum (PRE/SUB) | + | + | + | + | + | + |
| Cortical subplate and cerebral nuclei | ||||||
| Septohippocampal nucleus (SH) | + | + | + | + | + | + |
| Lateral septal nucleus, caudodorsal (LSc) | +++ | + | + | + | + | + |
| Lateral septal nucleus, rostroventral (LSr) | +++ | + | + | + | + | + |
| Bed nucleus of stria terminalis, principal nucleus (BSTpr) | ++++ | +++ | + | + | +++ | +++ |
| Cortical amygdalar area (COA) | +++ | +++ | + | + | +++ | +++ |
| Medial amygdalar nucleus, posterodorsal (MEApd) | +++ | + | + | + | +++ | +++ |
| Posterior amygdala (PA) | +++ | + | +++ | + | +++ | + |
| Thalamus and subthalamus | ||||||
| Ventral posterior complex of the thalamus (VP) | + | + | + | + | + | + |
| Paraventricular nucleus of the thalamus (PVT) | + | + | + | + | + | + |
| Nucleus of reuniens (RE) | +/− | +/− | + | + | ++ | + |
| Subthalamic/parasubthalamic, caudal (STN/PSTN) | ++ | + | + | + | ++ | ++ |
| Medial geniculate complex (MG) | + | + | + | + | ++ | + |
| Hypothalamus | ||||||
| Medial preoptic area, anterior (MPOa) | + | + | + | + | + | + |
| Medial preoptic area, posterior (MPOp) | ++++ | ++++ | ++++ | ++++ | ++++ | ++++ |
| Suprachiasmatic nucleus (SCH) | ++ | + | +/− | +/− | + | +/− |
| Paraventricular hypothalamic nucleus (PVH) | +/− | +/− | − | − | − | − |
| Periventricular hypothalamic nucleus (PV) | + | +/− | − | − | − | − |
| Subparaventricular zone (SBPV) | + | + | ++ | ++ | + | + |
| Lateral hypothalamic area (LHA) | +/− | +/− | − | − | − | − |
| Arcuate hypothalamic nucleus (ARH) | ++ | + | +/− | +/− | + | + |
| Ventromedial hypothalamic nucleus, ventrolateral (VMHvl) | + | ++ | + | + | ++ | + |
| Tuberal nucleus (TU) | + | + | − | − | + | + |
| Dorsomedial nucleus of the hypothalamus (DMH) | + | − | − | − | +/− | − |
| Dorsal premammillary nucleus (PMd) | + | + | ++ | ++ | ++ | ++ |
| Ventral premammillary nucleus (PMv) | ++++ | ++++ | +++ | +++ | +++ | +++ |
| Supramammillary nucleus (SUM) | + | +/− | + | + | + | +/− |
| Midbrain | ||||||
| Periaqueductal gray, ventrolateral (PAGvl) | +/− | +/− | +/− | +/− | + | + |
| Ventral tegmental area (VTA) | +/− | − | − | − | − | − |
| Red nucleus (RN) | +/− | − | − | − | +/− | −− |
| Dorsal raphe nucleus (DR) | +/− | +/− | +/− | +/− | + | + |
| Pons and medulla | ||||||
| Pontine reticular nucleus (PRN) | +/− | +/− | +/− | +/− | +/− | +/− |
| Superior olivary complex (SOC) | − | − | + | + | + | + |
| Principal sensory nucleus of the trigeminal (PSV) | − | − | + | +/− | + | − |
| Parabrachial nucleus (PB) | +/− | +/− | − | − | − | − |
| Dorsal tegmental nucleus (DTN) | + | + | + | + | + | + |
| Facial motor nucleus (VII) | + | +/− | + | + | + | + |
| Cochlear nuclei (CN) | +/− | − | + | + | + | + |
| Vestibular nucleus (VNC) | +/− | − | + | + | + | + |
| Nucleus ambiguus (AMB) | +/− | +/− | ++ | ++ | ++ | ++ |
| Hypoglossal nucleus (XII) | + | + | + | + | ++ | ++ |
| Nucleus of the solitary tract (NTS) | +/− | +/− | +/− | +/− | +/− | +/− |
| Dorsal motor nucleus of the vagus nerve (DMX) | + | + | + | + | ++ | ++ |
| Circumventricular organs | ||||||
| Subfornical organ (SFO) | +/− | + | + | + | +/− | +/− |
| Area postrema (AP) | +/− | +/− | +/− | +/− | + | + |
−, +/−, +, ++, +++, and ++++ represent not detected, very low, low, moderate, high, and very high expression of silver grain deposits corresponding to Ar mRNA. The Allen Mouse Brain Atlas was used as a reference for names, abbreviations, and location of nuclei.
Abbreviation: PND, postnatal day.