Table 1.
Phenotypic and Molecular Characterisation of 37 Multidrug-Resistant K. pneumoniae Clinical Isolates
| Isolate | Antibiotic Resistance Profile | MLST | ESBLs/ AmpC | Other Resistance Genes |
|---|---|---|---|---|
| Kp1 | CAZ, CTX, FEP, ATM, AMK, LEV, CIP | ST11 | blaCTX-M-15 | qnrS, rmtB |
| Kp2 | CAZ, CTX, FEP, ATM, GEN, AMK, LEV, CIP | ST304 | blaSHV-27 | qnrB, qnrS, armA |
| Kp3 | CAZ, CTX, FOX, ATM, AMK, LEV | ST2231 | blaDHA-1, blaCMY-2 | qnrS |
| Kp4 | CAZ, CTX, FEP, ATM, AMK, LEV, CIP | ST304 | blaCTX-M-15, blaOXA-10 | qnrB, qnrS, armA |
| Kp5 | CAZ, CTX, FEP, ATM, GEN, AMK, LEV, CIP | ST304 | blaCTX-M-15 | qnrB, qnrS, armA |
| Kp6 | CAZ, CTX, FEP, FOX, GEN, AMK, LEV, CIP | ST304 | blaDHA-1, blaCMY-2 | qnrB, qnrS, armA |
| Kp7 | CAZ, CTX, FOX, ATM, GEN, LEV, CIP | ST304 | blaDHA-1 | qnrA, qnrB, qnrS, armA |
| Kp8 | CAZ, CTX, FEP, ATM, AMK, LEV, CIP | ST37 | blaCTX-M-15 | qnrB, armA |
| Kp9 | CTX, FEP, GEN, AMK, CIP | ST716 | blaSHV-27 | qnrS |
| Kp10 | CAZ, ATM, GEN, AMK, LEV, CIP | ST828 | blaCTX-M-22 | ND |
| Kp11 | CAZ, CTX, GEN, CIP | ST268 | blaCTX-M-15 | qnrB, qnrS, armA |
| Kp12 | CAZ, ATM, AMK, LEV, CIP | ST65 | blaCTX-M-15 | ND |
| Kp13 | CAZ, CTX, FOX, ATM, GEN, AMK, LEV, CIP | ST37 | blaDHA-1 | qnrB, armA |
| Kp14 | CAZ, CTX, FEP, ATM, AMK, LEV, CIP | ST304 | blaCTX-M-15 | qnrB, qnrS, armA |
| Kp15 | CAZ, CTX, FEP, ATM, AMK, LEV, CIP | ST304 | blaTEM-53, blaCTX-M-15, blaDHA-1 | qnrS, armA |
| Kp16 | CAZ, CTX, FEP, FOX, ATM, GEN, AMK, LEV, CIP | ST304 | blaCTX-M-15, blaDHA-1 | qnrB, qnrS |
| Kp17 | CAZ, CTX, FEP, ATM, GEN, LEV, CIP | ST304 | blaCTX-M-15 | qnrB, qnrS |
| Kp18 | CAZ, CTX, FEP, ATM, AMK, LEV, CIP | ST37 | blaCTX-M-15, blaDHA-1 | qnrB, armA |
| Kp19a | CAZ, CTX, FEP, ATM, MEM, ERP, AMK, LEV, CIP | ST2232 | blaCTX-M-15 | rmtB |
| Kp20 | CAZ, CTX, FEP, AMK, LEV, CIP | ST716 | blaCTX-M-22 | qnrS |
| Kp21 | CAZ, CTX, FOX, ATM, GEN, AMK, CIP | ST304 | blaDHA-1 | qnrS |
| Kp22 | CAZ, CTX, FEP, GEN, AMK, LEV, CIP | ST716 | blaCTX-M-22, blaDHA-1 | qnrS |
| Kp23 | CAZ, CTX, FEP, ATM, GEN, AMK, LEV, CIP | ST304 | blaCTX-M-15 | qnrB, qnrS, armA |
| Kp24 | CAZ, CTX, ATM, AMK, LEV, CIP | ST304 | blaCTX-M-22 | qnrB, qnrS |
| Kp25a | CAZ, CTX, FEP, ATM, ERP, AMK, LEV, CIP | ST304 | blaCTX-M-14, blaDHA-1 | qnrB, qnrS, armA |
| Kp26 | CAZ, CTX, FEP, ATM, AMK, LEV, CIP | ST304 | blaTEM-53, blaCTX-M-15 | qnrS, armA |
| Kp27 | CAZ, CTX, FEP, ATM, AMK, LEV, CIP | ST304 | blaCTX-M-15, blaDHA-1 | qnrS |
| Kp28 | CAZ, CTX, FEP, ATM, AMK, LEV, CIP | ST15 | blaSHV-28, blaDHA-1 | qnrB |
| Kp29 | CAZ, CTX, FEP, ATM, AMK, CIP | ST1049 | blaCTX-M-14 | qnrB |
| Kp30 | CAZ, CTX, FEP, ATM, GEN, AMK, LEV, CIP | ST15 | blaSHV-28 | qnrB |
| Kp31 | CAZ, CTX, FEP, ATM, AMK, LEV, CIP | ST16 | blaTEM-53 | qnrS, armA |
| Kp32 | CAZ, CTX, FEP, FOX, ATM, GEN, AMK, LEV, CIP | ST17 | blaCTX-M-15, blaDHA-1 | qnrS |
| Kp33 | CAZ, CTX, FEP, FOX, ATM, GEN, AMK, LEV, CIP | ST18 | blaCTX-M-15, blaDHA-1, blaCMY-2 | qnrB, qnrS, armA |
| Kp34a | CAZ, CTX, FEP, FOX, ATM, GEN, AMK, LEV, CIP | ST19 | blaCTX-M-15, blaDHA-1, blaCMY-2 | qnrB, qnrS |
| Kp35 | CAZ, CTX, FEP, FOX, ATM, GEN, AMK, LEV, CIP | ST660 | blaCTX-M-15, blaDHA-1 | qnrB, qnrS, armA |
| Kp36 | CAZ, CTX, FOX, ATM, GEN, AMK, LEV, CIP | ST14 | blaDHA-1 | qnrB, qnrS, armA |
| Kp37 | CAZ, CTX, FEP, ATM, AMK, LEV, CIP | ST15 | blaCTX-M-14 | qnrS |
Note: aHad small colonies in the imipenem MIC gradient strips.
Abbreviations: CAZ, ceftazidime; CTX, cefotaxime; FEP, cefepime; FOX, cefoxitin; ATM, aztreonam; GEN, gentamicin; AMK, amikacin; LEV, levofloxacin; CIP, ciprofloxacin; MLST, multilocus sequence typing; ESBL, extended-spectrum β-lactamase; ST, sequence type; ND, not determined.