Table 2.
Analysis of the Presence of IPM Heteroresistance in Three MDR K. pneumoniae Isolates and Sequencing Profiles of ompK35 and ompK36 Genes
| Isolate | Original Carbapenems MIC (µg/mL) | Original Population Porin Sequencing | Population Analysis Profile | Resistant Subpopulations Porin Sequencing | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| IPM E-Test | IPM Microdilution |
MEM E-Test | ETP E-Test | ompK35 | ompK36 | Highest IPM Concn Grown (µg/mL) | Frequency of Heteroresistant Subpopulation | ompK35 | ompK36 | |
| Kp19 | 0.38 | 0.5 | 0.047 | 0.067 | WT | WT | 16 | 4.0×10−6 | WT | WT |
| Kp25 | 0.25 | 1 | 0.047 | 0.047 | WT | WT | 16 | 2.7×10−6 | WT | WT |
| Kp34 | 0.25 | 0.5 | 0.064 | 0.067 | WT | WT | 8 | 3.3×10−7 | WT | WT |
Abbreviations: IPM, imipenem; MEM, meropenem; ETP, ertapenem; WT, wild type.