Table 1.

Potential Drugs Against Drug-Resistant Bacteria with Their Reported Mechanism

Name	Source	Activity Against	Mechanism of Action	Highlights
Odilorhabdins (ODLs)	From the nematode symbiotic bacterium X. elegans	GNB and GPB, including carbapenemase producing Enterobacteriaceae	Inhibition of protein synthesis	• A novel binding site; • Drug concentration affects inhibition patterns
Teixobactin	From poorly cultivated soil microorganisms	GPB, including MDR strains	Inhibition of cell wall synthesis	• Novel antimicrobial mechanism; • No significant toxic side effects
G0775	Optimized the structure of arylomycin	GNB, including ESKAPE pathogenic bacteria	Inhibition of SPase	• The way to reach the target is novel
Malacidins	From the soil microorganisms	GPB, including MDR strains	Interaction with lipid II in a calcium-dependent manner	• No cytotoxic effects
Darobactin	From the screening of Photorhabdus isolates	GNB, including MDR strains	Damage in the outer membrane	• Novel antimicrobial mechanism; • No cytotoxic effects
Halicin	From artificial intelligence	GPB and GNB, including MDR strains	Interruption of the transmembrane electrochemical gradient	• Novel antimicrobial mechanism
Pseudouridimycin (PUM)	From the microorganisms in soil samples	GPB and GNB, including MDR strains	Inhibition of bacterial RNAP by blocking transcription	• Selectively inhibit bacterial RNAP; • Different binding site