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NMDARs induce neural toxicity through the GluN2B-postsynaptic density protein 95-nNOS axis. NMDAR, N-methyl-D-aspartate receptor; GluN2B, NMDAR receptor 2B; nNOS, neuronal nitric oxides synthase; PDZ, PSD95 discs-large and zona occludens-1; Tat-NR2B9c, postsynaptic density 95 blocking peptide; ZL006, a small-molecular inhibitor of the nNOS-PSD-95 interaction; SH3, Src Homology 3; GK, guanylate kinase.
