Table 2:
Who should undergo genetic risk assessment? *
| Consensus question | Yes | No |
|---|---|---|
|
| ||
| Should an individual with renal tumors and syndromic manifestations associated with hereditary kidney cancer be offered genetic risk assessment? | 100% | 0% |
|
| ||
| Should an individual without renal tumors and syndromic manifestations associated with hereditary kidney cancer be offered genetic risk assessment? | 100% | 0% |
|
| ||
| Should an individual with renal tumors and a first degree family member with syndromic manifestations (ex. pheochromocytoma, melanoma, pneumothorax) associated with hereditary kidney cancer be offered genetic risk assessment? | 96% | 4% |
|
| ||
| Should an individual without renal tumors and a first degree family member with worrisome syndromic manifestations (ex. pheochromocytoma, melanoma, pneumothorax) associated with hereditary kidney cancer be offered genetic risk assessment? | 95% | 5% |
|
| ||
| For an individual with or without renal tumor(s) but first degree relatives with documented germline mutation associated with RCC should genetic risk assessment be offered? | 100% | 0% |
|
| ||
| For an individual with or without renal tumor(s) but a second degree family member with documented germline mutation associated with RCC should genetic risk assessment be offered before testing the first degree relative? | 53% | 47% |
|
| ||
| For an individual with or without renal tumor(s) but second degree relatives with documented germline mutation associated with RCC and inability to test first degree relative should genetic risk assessment be offered? | 90% | 10% |
|
| ||
| For an individual with a renal tumor(s) and a first degree relative with RCC should genetic risk assessment be offered? | 90% | 10% |
|
| ||
| For an individual with a renal tumor(s) and two second degree relatives (same lineage) with RCC should genetic risk assessment be offered? | 87% | 13% |
|
| ||
| For an individual with a renal tumor(s) and one second degree relative with RCC with unknown histology should genetic risk assessment be offered? | 20% | 80% |
|
| ||
| For an individual without a renal tumor(s) and first degree relative(s) with RCC should genetic risk assessment be offered? | 23% | 77% |
|
| ||
| For an individual without a renal tumor(s) and one second degree relative with RCC should genetic risk assessment be offered? | 11% | 89% |
|
| ||
| In the absence of syndromic manifestations, should individuals with bilateral or multifocal renal tumors be offered genetic risk assessment? | 93% | 7% |
|
| ||
| Are there specific renal tumor histologies that should lead to recommendations for genetic risk assessment? | 97% | 3% |
|
| ||
| Is needle biopsy (without resected pathology) sufficient to pursue genetic risk assessment? | 73% | 27% |
|
| ||
| For individuals with histology suggestive of an SDH renal tumor, should genetic risk assessment be offered? | 100% | 0% |
|
| ||
| For individuals with histology suggestive of an FH deficient renal tumor, should genetic risk assessment be offered? | 100% | 0% |
|
| ||
| For individuals with histology suggestive of a hybrid renal tumor (Oncocytoma and chromophobe), should genetic risk assessment be offered? | 86% | 14% |
|
| ||
| Should those with bilateral or multifocal chromophobe RCC be recommended for genetic risk assessment? | 93% | 7% |
|
| ||
| Should those with bilateral or multifocal papillary type 1 RCC be recommended for genetic risk assessment? | 85% | 15% |
|
| ||
| Should those with bilateral or multifocal clear cell RCC be recommended for genetic risk assessment? | 93% | 7% |
|
| ||
| Should those with bilateral or multifocal renal angiomyolipomas be recommended for genetic risk assessment? | 86% | 14% |
|
| ||
| Should age be a sole criterion for genetic risk assessment? | 70% | 30% |
|
| ||
| If an age cutoff was recommended for genetic risk assessment based on SEER age distributions, what age do you feel this should be? | ||
| a) 54 years of age (25th percentile) 17% | 17% | |
| b) 46 years of age (10th percentile) 67% | 67% | |
| c) 40 years of age (5th percentile) 7% | 7% | |
| d) 36 years of age (2.5th percentile) | 10% | |
*
Statements in bold represent those with reached consensus