Table 4:

What type of genetic testing should be performed?^*

Consensus question	Single-gene	Multigene
In general, should individuals with suspicion for a classic syndrome be considered for single gene or multigene panel testing?	83%	17%
In general, should individuals without suspicion of a classic syndrome but at least one risk factor for hereditary kidney cancer be considered for single gene or multigene panel testing?	10%	90%
	Yes	No
An individual with kidney cancer undergoes somatic tumor profiling and is found with an alteration in a cancer gene associated with hereditary RCC (not VHL), in the absence of risk factors, should this individual undergo genetic risk assessment?*	21%	79%**
If the above individual were to pursue genetic risk assessment for an alteration identified on a somatic panel, should testing consist of a single-gene assay?	97%	3%
Should a negative somatic tumor profiling report (without germline testing) influence the decision to pursue genetic risk assessment?	39%	61%

^*Statements in bold represent those with reached consensus

^**79% voted that the response to this question depends on the specific gene in question.