Table 2.

Metabolites perturbed in pancreatic islets exposed to arsenicals as compared to unexposed controls (Ctrl)

Codea	Metaboliteb	Fold Changec
		iAsIII vs Ctrl	MAsIII vs Ctrl	DMAsIII vs Ctrl
A	Suberic acid	1.0	−1.0	1.0
	Petroselinic acid	1.0	1.0	1.0
B	S-Adenosyl-L-methionine	−1.5	−1.9
	Glutamic acid	−1.0	−1.0
D	Citrulline		−2.0	−2.4
	Uric acid		2.3	−2.3
	Ophthalmic acid		1.5	1.4
	Acetylcarnitine		−1.2	−1.3
	Glyceryl monomyristate		1.0	−1.1
	4-Imidazoleacrylic acid		−2.2	−2.7
E	Sucrose	2.3
	Azelaic acid	1.0
	Taurine	−1.2
	Aspartic acid	−1.1
	Leucine	−1.0
	Hypoxanthine	−1.0
	Hypotaurine	3.9
	Sorbitol	2.5
	Orotic acid	−1.6
	Galactose	−1.1
	Valine	−1.1
F	Tyrosine		−1.1
	Methylthioadenosine		−1.6
	Betaine		−2.1
	Lysine		2.4
G	Glutathione reduced			−2.1
	Ornithine			−1.3
	4-Hydroxyphenylpyruvic acid			1.0
	2,6-Diaminopimelic acid			1.2

^aCapital letters (A-G) correspond to the area codes in Venn diagram in Fig. 4b.

^bMetabolites satisfying VIP≥ 1.0 or p<0.05 or |FC|>2.0 in pairwise comparison of the arsenical-treated and control islets.

^cFold Change, the ratio of intensity between the arsenical treated islets vs the control islets, based on the mean, indicates the direction and magnitude of change: positive FC indicates increase compared to control and negative FC indicates decrease compared to control. Lack of FC value (gray area) indicates that the metabolite did not satisfy the above criteria.