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. 2021 Dec 13;11:748691. doi: 10.3389/fonc.2021.748691

Table 2.

Final survival model of the prognostic score.

Characteristic Final AFT model
Coefficient§ SE AF p
Intercept 3.2403 0.2046 <0.0001
RTV >10 to ≤20 cm3 −0.4717 0.1905 0.624 0.0133
RTV >20 cm3 −0.7840 0.1498 0.457 <0.0001
Age >50 to ≤70 −0.3057 0.1169 0.734 0.0089
Age >70 −0.4798 0.1624 0.619 0.0031
MGMT, unmethylated −0.4131 0.0834 0.662 <0.0001
Radiotherapy 0.1512 0.1570 1.170 0.3356
Radiochemotherapy 0.4905 0.1697 1.633 0.0039
Resectability, bad −0.2272 0.1066 0.797 0.0330
Infiltration of vent. wall −0.3274 0.0810 0.721 <0.0001
Log(scale) −0.9845 0.0527 <0.0001
Pseudo R2 0.423
C-index 0.749

RTV, residual tumor volume; MGMT, O6-methylguanine-DNA-methyltransferase; AFT, accelerated failure time.

§ The coefficients in the log-logistic model detect acceleration or deceleration in survival times [acceleration factor (AF)]. The transformation with the exponential function leads to values <1 (delay—disadvantageous) or >1 (acceleration—advantageous). For example, the factor MGMT with exp(−0.4131) = 0.66 is associated with a survival time for unmethylated versus methylated shortened by a factor of 0.66.