Table 2.
Final survival model of the prognostic score.
Characteristic | Final AFT model | |||
---|---|---|---|---|
Coefficient§ | SE | AF | p | |
Intercept | 3.2403 | 0.2046 | <0.0001 | |
RTV >10 to ≤20 cm3 | −0.4717 | 0.1905 | 0.624 | 0.0133 |
RTV >20 cm3 | −0.7840 | 0.1498 | 0.457 | <0.0001 |
Age >50 to ≤70 | −0.3057 | 0.1169 | 0.734 | 0.0089 |
Age >70 | −0.4798 | 0.1624 | 0.619 | 0.0031 |
MGMT, unmethylated | −0.4131 | 0.0834 | 0.662 | <0.0001 |
Radiotherapy | 0.1512 | 0.1570 | 1.170 | 0.3356 |
Radiochemotherapy | 0.4905 | 0.1697 | 1.633 | 0.0039 |
Resectability, bad | −0.2272 | 0.1066 | 0.797 | 0.0330 |
Infiltration of vent. wall | −0.3274 | 0.0810 | 0.721 | <0.0001 |
Log(scale) | −0.9845 | 0.0527 | <0.0001 | |
Pseudo R2 | 0.423 | |||
C-index | 0.749 |
RTV, residual tumor volume; MGMT, O6-methylguanine-DNA-methyltransferase; AFT, accelerated failure time.
§ The coefficients in the log-logistic model detect acceleration or deceleration in survival times [acceleration factor (AF)]. The transformation with the exponential function leads to values <1 (delay—disadvantageous) or >1 (acceleration—advantageous). For example, the factor MGMT with exp(−0.4131) = 0.66 is associated with a survival time for unmethylated versus methylated shortened by a factor of 0.66.