TABLE 2.

Dynamic ubiquitin decorations of STING.

Target protein	PTM sites	Enzyme	Decoration type	Function	References
STING	K288/337	TRIM29	Ubiquitination (K48)	Promotes STING proteasomal degradation	Li et al., 2018
	K150	RNF90	Ubiquitination (K48)	Induces STING degradation	Yang et al., 2020
	K236	USP44	Deubiquitination (K48)	Promotes STING stability	Zhang et al., 2020a
	K347	OTUD5	Deubiquitination (K48)	Prevents STING degradation	Guo Y. et al., 2021
	K20/150/224/236	TRIM32	Ubiquitination (K63)	Increases STING interaction with TBK1	Zhang et al., 2012
	–	USP49	Deubiquitination (K63)	Improves STING aggregation and translocation	Ye et al., 2019
	K150	MYSM1	Deubiquitination (K63)	Attenuates STING activation	Tian et al., 2020