TABLE 4.
Modifications of IRF3 during virus infection.
| Target protein | PTM sites (h:human,m:mice) | PTM | Enzymes | Function | References |
| IRF3 | K98 (h) | Deubiquitination (K6) | OTUD1 | Restricts IRF3 DNA binding | Zhang et al., 2020e |
| K193/360/366(m) | ISGylation | HERC5 | Stabilizes IRF3 | Shi et al., 2010 | |
| K366(m) | Monomethylation | NSD3 | Ensures IRF3 subsequent phosphorylation | Wang et al., 2017 | |
| K366(m) | Dephosphorylation | PP1cc | Dephosphorylate IRF3 | Wang et al., 2017 | |
| K359(m) | Acetylation | KAT8 | Reduces IRF3 induced gene transcriptions | Huai et al., 2019 |