Table 2.
Physical and Morphological Properties of the Prepared Nanoparticles
| Nanoparticles | HD±SD (nm) | PDI±SD | Zeta±SD (mV) | Drug loading (mg/g) | EE (%) | ||
|---|---|---|---|---|---|---|---|
| ST | GNPs | ST | GNPs | ||||
| Empty PLGA | 205.5±3.1 | 0.022±0.05 | −20.1±1.9 | – | – | – | – |
| ST/PLGA | 222.1±4.4 | 0. 172±0.11 | −22.8±0.6 | 54.2±2.2 | – | 40.1±2.6 | – |
| G/PLGA | 256.9±2.9 | 0.152±0.08 | −26.1±0.9 | – | 44.1±2.3 | – | 61.2±2.5 |
| ST+G/PLGA | 299.8±6.2 | 0.216±0.13 | −27.5±2.2 | 50.6±3.4 | 38.2±1.1 | 38.9±1.6 | 55.8±1.3 |
| Empty PCL | 265.4±4.2 | 0.205±0.21 | −14.1±1.9 | – | – | – | – |
| ST/PCL | 276.1±3.2 | 0. 256±0.27 | −12.8±0.6 | 44.6±4.5 | – | 38.5±1.8 | – |
| G/PCL | 314.9±3.9 | 0.298±0.18 | −13.9±0.9 | – | 35.2±2.9 | – | 21.5±2.6 |
| ST+G/PCL | 355.8±6.4 | 0.282±0.14 | −14.8±1.2 | 38.9±3.9 | 29.6±3.1 | 33.8±1.6 | 19.8±2.2 |
Note: Data represent the mean ±- SD, n=3.
Abbreviations: ALG, alginate; EE, encapsulation efficiency; HD, hydrodynamic diameter assessed by DLS; HG, hexagonal gold nanoparticles; ST, sorafenib tosylate; PDI, polydispersity index; SD, standard deviation; Zeta, zeta potential.