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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Exp Neurol. 2021 Nov 6;347:113914. doi: 10.1016/j.expneurol.2021.113914

Fig. 1.

Fig. 1.

Placental-derived mediators drive neural injury in CHORIO. Sham or CHORIO placental explants were cultured on inserts and placental conditioned media (PCM) assayed for toxic mediators and inflammatory drivers (A-B). CHORIO placentas secrete more IL-1β (A), and TNF-α (B) compared to sham placentas. To determine the effect of CHORIO PCM on the developing brain, PCM from naive or CHORIO placental explants was cultured with postnatal day 2 (P2) brain slices (C). PCM from CHORIO placental explants induced high levels of CXCL1 in P2 brain slices. (n = 4–5, two independent experiments, *p < 0.05, **p < 0.01, ***p < 0.001).