Table 5.
Predictors of total and daily colistin dosages as the risks of acute kidney injury and benefactors of mortality reduction.
| OR (95% CI) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | LRP | LRN | |
|---|---|---|---|---|---|---|---|
| Risks for colistin-induced AKI | |||||||
| Non-AKI before colistin (n = 294) | |||||||
| Daily colistin dose/IBW (AUCROC 0.57) | |||||||
| >4.0 mg/kg/day | 2.59 (1.25–5.37) | 92.3 | 17.9 | 64.5 | 58.8 | 1.12 | 0.43 |
| >4.5 mg/kg/day | 1.75 (1.05–2.90) | 75.1 | 36.6 | 65.7 | 47.7 | 1.19 | 0.68 |
| >5.0 mg/kg/day | 1.48 (0.93–2.38) | 58.0 | 51.8 | 66.0 | 43.3 | 1.20 | 0.81 |
| Daily colistin dose/BW (AUCROC 0.55) | |||||||
| >5.5 mg/kg/day | 1.60 (1.00–2.59) | 50.0 | 61.1 | 67.9 | 43.1 | 1.30 | 0.81 |
| Total colistin dose (AUCROC 0.63) | |||||||
| >1,500 mg | 2.49 (1.41–4.40) | 85.1 | 30.4 | 66.4 | 55.7 | 1.22 | 0.49 |
| >2,000 mg | 2.01 (1.19–3.40) | 79.0 | 34.8 | 66.2 | 50.6 | 1.21 | 0.60 |
| >2,500 mg | 3.04 (1.87–4.95) | 66.3 | 60.7 | 73.2 | 52.7 | 1.69 | 0.56 |
| >3,000 mg | 1.95 (1.20–3.19) | 48.1 | 67.9 | 70.7 | 44.7 | 1.50 | 0.77 |
| Total colistin dose/IBW (AUCROC 0.65) | |||||||
| >45 mg/kg | 3.29 (2.02–5.37) | 67.2 | 61.6 | 73.8 | 53.9 | 1.75 | 0.53 |
| >50 mg/kg | 2.68 (1.65–4.37) | 58.9 | 65.2 | 73.1 | 49.7 | 1.69 | 0.63 |
| AKI before colistin (n = 118) | |||||||
| Total colistin dose (AUCROC 0.62) | |||||||
| >1,000 mg | 3.21 (1.18–8.76) | 72.0 | 55.6 | 90.0 | 26.3 | 1.62 | 0.50 |
| >1,200 mg | 2.92 (1.07–7.97) | 65.0 | 61.1 | 90.3 | 23.9 | 1.67 | 0.57 |
| >1,250 mg | 3.74 (1.28–10.9) | 59.0 | 72.2 | 92.2 | 24.1 | 2.12 | 0.57 |
| >1,350 mg | 3.59 (1.23–10.4) | 58.0 | 72.2 | 92.1 | 23.6 | 2.09 | 0.58 |
| Total colistin dose/IBW (AUCROC 0.61) | |||||||
| >20.0 mg/kg | 3.66 (1.30–10.2) | 64.6 | 66.7 | 91.4 | 25.5 | 1.94 | 0.53 |
| >22.5 mg/kg | 3.83 (1.31–11.1) | 59.6 | 72.2 | 92.2 | 24.5 | 2.15 | 0.56 |
| >23.5 mg/kg | 3.12 (1.07–9.04) | 54.5 | 72.2 | 91.5 | 22.4 | 1.96 | 0.63 |
| >24.0 mg/kg | 3.00 (1.03–8.68) | 53.5 | 72.2 | 91.4 | 22.0 | 1.93 | 0.64 |
| Predictors for improved survival | |||||||
| Non-AKI before colistin (n = 294) | |||||||
| Total colistin dose (AUCROC 0.57) | |||||||
| >1,500 mg | 2.20 (1.16–4.17) | 89.0 | 21.4 | 64.7 | 54.5 | 1.13 | 0.52 |
| >2,000 mg | 2.08 (1.23–3.53) | 79.6 | 34.8 | 66.4 | 51.3 | 1.22 | 0.59 |
| Total colistin dose/IBW (AUCROC 0.57) | |||||||
| >25 mg/kg | 2.21 (1.19–4.11) | 87.8 | 23.4 | 65.2 | 54.2 | 1.15 | 0.52 |
| >30 mg/kg | 1.84 (1.07–3.17) | 80.7 | 30.6 | 65.5 | 49.3 | 1.16 | 0.63 |
| >35 mg/kg | 2.20 (1.33–3.66) | 75.7 | 41.4 | 67.8 | 51.1 | 1.29 | 0.59 |
Note. OR: odd ratio, PPV: positive predictive value, NPV: negative predictive value, LRP: likelihood ratio for positive results, and LRN: likelihood ratio for negative results.