Table 1.
Demographic, clinical and histological characteristics of study subjects.
| Hispanics | Caucasians | p-value | |||||
|---|---|---|---|---|---|---|---|
| NAFL | HC | NAFL | HC | a | b | c | |
| Liver, n (F/M) | 7 (5/2) | - | 10 (5/5) | - | |||
| Plasma, n (F/M) | 7 (5/2) | 14 (6/8) | 8 (4/4) | 8 (4/4) | |||
| Age (Yrs.) | 45 ± 16 | 43 ± 14 | 50 ± 16 | 44 ± 12 | 0.818 | 0.413 | 0.55 |
| BMI (Kg/m2) | 47 ± 7 | 26 ± 2 | 42 ± 7 | 25 ± 3 | <.0001 | <.0001 | 0.28 |
| DM, yes (%) | 3 (42.9) | - | 4 (40) | - | - | - | 0.913 |
| FBG mmol/L | 93 ± 5 | - | 94 ± 13 | - | - | - | 0.88 |
| Cholesterol (mg/dL) | 168 ± 29 | - | 173 ± 33 | - | - | - | 0.952 |
| TG (mg/dL) | 112 ± 37 | - | 139 ± 65 | - | - | - | 0.42 |
| HDL (mg/dL) | 44 ± 7 | - | 41 ± 8 | - | - | - | 0.403 |
| LDL (mg/dL) | 102 ± 23 | - | 104 ± 33 | - | - | - | 0.855 |
| HbA1c (%) | 6.1 ± 0.7 | - | 6.2 ± 0.8 | - | - | - | 0.67 |
| AST (U/L) | 27 ± 12 | - | 31 ± 19 | - | - | - | 0.499 |
| ALT (U/L) | 34 ± 18 | - | 31 ± 10 | - | - | - | 0.752 |
| Platelet | 308 ± 58 | - | 292 ± 100 | - | - | - | 0.506 |
| NAS | 2.43 ± 2.40 | - | 3 ± 1.5 | - | - | - | 0.653 |
| NASH, yes (%) | 6 (60) | - | 5 (50) | - | - | - | 0.708 |
| Steatosis (%) | |||||||
| < 5% | 3 (42.8) | - | 2 (20) | - | - | - | 0.452 |
| 5 to ≤ 33% | 2 (28.6) | - | 5 (50) | - | - | - | |
| 34 to ≤ 66 % | 2 (28.6) | - | 2 (20) | - | - | - | |
| > 66% | 0 (0) | - | 1 (10) | - | - | - | |
| Inflammation (%) | |||||||
| None | 3 (42.9) | - | 1 (10) | - | - | - | 0.763 |
| Mild | 1 (14.3) | - | 6 (60) | - | - | - | |
| Moderate | 2 (28.6) | - | 3 (30) | - | - | - | |
| Severe | 1 (14.3) | - | 0 (0) | - | - | - | |
| Ballooning (%) | |||||||
| None | 4 (57) | - | 5 (50) | - | - | - | 0.772 |
| Few | 3 (42.9) | - | 5 (50) | - | - | - | |
| Many | 0 (0) | - | 0 (0) | - | - | - | |
| Fibrosis (%) | |||||||
| None | 7 (100) | - | 9 (90) | - | - | - | 0.998 |
| 1A | 0 (0) | - | 1 (10) | - | - | - | |
| 2 | 0 (0) | - | 0 (0) | - | - | - | |
| 4 | 0 (0) | - | 0 (0) | - | - | - | |
General characteristics are shown as percent (for categorical data) and mean ± SEM (for nominal data). Group comparisons were performed by chi-square test (categorical) or t- test (nominal). (a) NAFL-HIS vs. HC-HIS; (b) NAFL-CAU vs. HC-CAU; (c) NAFL-HIS vs. NAFL-CAU. ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; DM, diabetes mellitus; FBG, fasting blood glucose; HbA1c, hemoglobin A1c; HDL, high-density lipoprotein; LDL, low density lipoprotein; NAS, the NAFLD Activity Score; TG, triglycerides.