Table 2.
Demographic, clinical and histological characteristics of subjects with NASH.
| Hispanics | Caucasians | p-value | ||||
|---|---|---|---|---|---|---|
| 0 NASH | NASH | 0 NASH | NASH | a | b | |
| Liver, n (F/M) | 4(3/1) | 3(2/1) | 5(3/2) | 5(2/3) | ||
| Plasma, n (F/M) | 4(3/1) | 3(2/1) | 5(3/2) | 3(1/2) | ||
| Age (Yrs.) | 45 ± 21 | 46 ± 10 | 54 ± 19 | 45 ± 14 | 0.872 | 0.405 |
| BMI (Kg/m2) | 47.4 ± 7.9 | 45.7 ± 6.7 | 39.9 ± 4.4 | 44.4 ± 3.8 | 0.787 | 0.406 |
| FBG mmol/L | 93 ± 5 | 94 ± 4 | 98 ± 15 | 90 ± 10 | 0.873 | 0.379 |
| TG (mg/dL) | 105 ± 39 | 121 ± 40 | 120 ± 80 | 157 ± 50 | 0.59 | 0.35 |
| AST (U/L) | 20 ± 3 | 36 ± 14 | 21 ± 3 | 40 ± 23 | 0.064 | 0.0276 |
| ALT (U/L) | 23 ± 9 | 48 ± 18 | 25 ± 2.2 | 38 ± 11 | 0.0431 | 0.0246 |
| Steatosis | 12 ± 19 | 22.7 ± 9.3 | 15.6 ± 15.5 | 32.2 ± 21.8 | 0.197 | 0.1474 |
| NAS | 0.75 ± 1.1 | 4.7 ± 0.6 | 1.8 ± 1 | 4 ± 1 | 0.004 | 0.017 |
| Inflammation (%) | ||||||
| None | 3(75) | 0(0) | 1(20) | 0(0) | 0.998 | 0.323 |
| Mild | 1(25) | 0(0) | 3(60) | 3(60) | ||
| Moderate | 0(0) | 2(66.7) | 1(20) | 2(40) | ||
| Severe | 0(0) | 1(33.3) | 0(0) | 0(0) | ||
| Ballooning (%) | ||||||
| None | 4(100) | 0(0) | 5(100) | 0(0) | <0.0001 | <0.0001 |
| Few | 0(0) | 3(100) | 0(0) | 5(100) | ||
| Many | 0(0) | 0(0) | 0(0) | 0(0) | ||
| Fibrosis (%) | ||||||
| None | 4(100) | 3(100) | 5(100) | 4(80) | 1 | 0.998 |
| 1A | 0(0) | 0(0) | 0(0) | 1(20) | ||
| 2 | 0(0) | 0(0) | 0(0) | 0(0) | ||
| 3 | 0(0) | 0(0) | 0(0) | 0(0) | ||
| 4 | 0(0) | 0(0) | 0(0) | 0(0) | ||
General characteristics are shown as percent (for categorical data) and mean ± SEM (for nominal data). Comparison were performed by t- test (nominal) or chi-square test (categorical). (a) NASH-HIS vs. 0-NASH-HIS; (b) NASH-CAU vs. 0-NASH-CAU. ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; FBG, fasting blood glucose; NAS, the NAFLD Activity Score; NASH, Nonalcoholic steatohepatitis; 0-NASH, Nonalcoholic steatohepatitis-free; TG, triglycerides.