Table I.
Clinical characteristics of AD cases versus age, sex, and race matched controls in All of Us
| Matched controls | AD cases | P value | |
|---|---|---|---|
| N | 47008 | 11752 | |
| Age, mean (SD) | 59.16 (16.22) | 59.15 (16.22) | .994 |
| Female (%) | 31781 (67.6) | 7946 (67.6) | .998 |
| Race/ethnicity (%) | 1.000 | ||
| Asian | 1632 (3.5) | 409 (3.5) | |
| Black | 8159 (17.4) | 2038 (17.3) | |
| Hispanic | 7224 (15.4) | 1805 (15.4) | |
| Other | 1420 (3.0) | 355 (3.0) | |
| White | 28573 (60.8) | 7145 (60.8) | |
| COVID-19 (%) | 1313 (2.8) | 492 (4.2) | <.001 |
| Ever smoker (%) | 19159 (40.8) | 4547 (38.7) | <.001 |
| BMI, mean (SD) | 29.87 (7.52) | 30.32 (7.58) | <.001 |
| Hypertension (%) | 23007 (48.9) | 6979 (59.4) | <.001 |
| Hyperlipidemia (%) | 22218 (47.3) | 7458 (63.5) | <.001 |
| Type II DM (%) | 9513 (20.2) | 3253 (27.7) | <.001 |
| Atrial fibrillation (%) | 4049 (8.6) | 1198 (10.2) | <.001 |
| Sleep apnea (%) | 3185 (6.8) | 1131 (9.6) | <.001 |
| Ischemic heart disease (%) | 3351 (7.1) | 1312 (11.2) | <.001 |
| Stroke (%) | 2110 (4.5) | 739 (6.3) | <.001 |
| Cardiovascular disease (%) | 4951 (10.5) | 1829 (15.6) | <.001 |
| HIV (%) | 693 (1.5) | 288 (2.5) | <.001 |
| HCV (%) | 1394 (3.0) | 452 (3.8) | <.001 |
| Thyroiditis (%) | 1022 (2.2) | 493 (4.2) | <.001 |
| Hypothyroidism (%) | 7319 (15.6) | 2582 (22.0) | <.001 |
| Hyperthyroidism (%) | 1302 (2.8) | 652 (5.5) | <.001 |
| Malignancy (%) | 9377 (19.9) | 3603 (30.7) | <.001 |
| Autoimmune disease∗ (%) | 3732 (7.9) | 1764 (15.0) | <.001 |
BMI, Body mass index; DM, diabetes mellitus; HCV, hepatitis C virus.
∗
Autoimmune disease includes systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, thyroiditis, vitiligo, and alopecia areata.