Table 1.
Comparison of clinico-biological characteristics of antibiotic and non-antibiotic groups at admission.
| Total | Without antibiotics | With antibiotics | p | |
|---|---|---|---|---|
| N (%) | 149 | 48 (32.2) | 101 (67.8) | |
| Age (years), median [IQR] | 85.50 [82.00, 89.00] | 86.00 [83.00, 90.00] | 85.00 [82.00, 88.00] | 0.560 |
| Sex, N (%) | 0.428 | |||
| Male | 66 (44.3) | 19 (39.6) | 47 (46.5) | |
| Female | 83 (55.7) | 29 (60.4) | 54 (53.5) | |
| Living place, N (%) | 0.619 | |||
| Nursing Home | 38 (25.5) | 11 (22.9) | 27 (26.7) | |
| Home | 111 (74.5) | 37 (77.1) | 74 (73.3) | |
| Number of Medications before hospitalization, mean (SD) | 7.38 (3.33) | 6.73 (2.83) | 7.69 (3.51) | 0.074 |
| Charlson Comorbidity Index, median [Q1, Q3] | 6.00 [5.00, 7.00] | 6.00 [5.00, 7.00] | 6.00 [5.00, 7.00] | 0.306 |
| Infection COVID-19, N (%) | 0.659 | |||
| Nosocomiala | 25 (16.8) | 9 (18.8) | 16 (15.8) | |
| Community | 124 (83.2) | 39 (81.2) | 85 (84.2) | |
| MDRDb at admission, median [Q1, Q3] | 62.00 [42.25, 94.00] | 73.00 [53.00, 96.00] | 57.00 [40.00, 91.25] | 0.057 |
| Corticoids, N (%) | 25 (16.8) | 2 (4.2) | 23 (22.8) | 0.005 |
| Thromboprophylaxis (%) | 111 (74.5) | 33 (68.8) | 78 (77.2) | 0.271 |
| CRPc at admission, median [Q1, Q3] | 86.95 [35.77, 154.47] | 48.80 [16.20, 83.40] | 107.65 [55.88, 166.93] | < 0.001 |
| Haemoglobin at admission, mean (SD) | 12.42 (1.85) | 11.99 (2.02) | 12.62 (1.74) | 0.062 |
| Leucocytes at admission, median [Q1, Q3] | 6.92 [5.10, 10.00] | 6.10 [4.90, 8.50] | 7.15 [5.30, 10.38] | 0.169 |
| Saturation at admission, median [Q1, Q3] | 95.00 [93.00, 97.00] | 95.00 [94.00, 97.00] | 95.00 [92.25, 97.00] | 0.342 |
| Oxygen at admission, median [Q1, Q3] | 2.00 [0.00, 4.00] | 0.00 [0.00, 3.00] | 3.00 [1.00, 4.00] | < 0.001 |
| Temperature (°C), mean (SD) | 37.03 (0.88) | 36.97 (0.73) | 37.06 (0.95) | 0.557 |
IQR: interquartile range, SD: standard deviation.
The NA were imputed by simple imputation to not exclude patients in the following analyses
Maximum of 3 non applicable for a variable.
Binary variables: imputation by the most frequent modality.
Continuous variables: imputation by the median.
a
nosocomial infection: infection occurring in a patient during the process of care in a hospital or other health care facility, which was not present or incubating at the time of admission [36].
b
MDRD: modification of diet in renal disease.
c
CRP: C-reactive protein.