Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 28;38(3):110271. doi: 10.1016/j.celrep.2021.110271

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

PMC Copyright notice

The hypothetic model of immune dysregulation and increased ROS that induces renal injuries in patients with severe COVID-19

(A) Pathways are displayed in square boxes, proteins are displayed in circles, while metabolites are displayed in hexagons. The Z score of the activity of a pathway is displayed as dots beside the respective pathway in a red (for serum) or blue (for urine) box, with its size representing the log₁₀(p value) of each pathway and its color representing the Z score value. Relative protein or metabolite expression is labeled beside the respective molecule. ^aRho, regulation of actin-based motility by Rho.

(B) Serum DEPs involved in the acute phase response and leukocyte extravasation signaling.

(C) Serum DEPs involved in the coagulation system.

(D) Serum DEPs involved in the actin cytoskeleton and Rho signaling.

(E) Urine DEPs involved in the ephrin receptor signaling, sphingosine-1-phosphate signaling, and adrenomedullin signaling. The relative expression values of proteins are shown in the pie chart.

HHS Vulnerability Disclosure