REAGENT or RESOURCE	SOURCE	IDENTIFIER
Biological samples
Serum samples	Taizhou Hospital	This paper (Table S1_Patient ID)
Urine samples	Taizhou Hospital	This paper (Table S1_Patient ID)
Chemicals, peptides, and recombinant proteins
Triethylammonium bicarbonate buffer (TEAB)	Sigma-Aldrich	Cat # T7408
Urea	Sigma-Aldrich	Cat # U1250
Tris (2-carboxyethyl) phosphine (TCEP)	Adamas-beta	Cat # 61820E
Iodoacetamide (IAA)	Sigma-Aldrich	Cat # I6125
Trypsin	Hualishi Tech	Cat # HLS TRY001C
Lys-C	Hualishi Tech	Cat # HLS LYS001C
Trifluoroacetic acid (TFA)	Thermo Fisher Scientific	Cat # 85183
Water	Thermo Fisher Scientific	Cat # W6-4
Acetonitrile	Thermo Fisher Scientific	Cat # A955-4
Formic acid (FA)	Thermo Fisher Scientific	Cat # A117-50
Ammonium hydroxide solution	Sigma-Aldrich	Cat # 221228
Methanol	Sigma-Aldrich	Cat # 3486
Critical commercial assays
TMTpro 16plex reagents	Thermo Fisher Scientific	Cat # A44520
Creatinine	Beckman	Cat # OSR6178
Glucose	Beckman	Cat # GL7210
SARS-CoV-2 nucleic acid detection kit-1	Shanghai Zhijiang	Cat # Z-RR-0479-02025
SARS-CoV-2 nucleic acid detection kit-2	Shanghai Zhijiang	Cat # Z-RR-0479-02-50
SARS-CoV-2 nucleic acid detection kit-3	Shanghai Zhijiang	Cat # Z-RR-0479-02AT-5002025
Urine creatinine	Beckman Coulter	Cat # OSR6178
Urine pH value	Guilin URIT	Cat #56208349
Urine specific gravity	Guilin URIT	Cat #56208349
High Select™ Top-14 Abundant Protein Depletion Mini Spin Columns	Thermo Fisher Scientific	Cat #A36370
SOLAμ	Thermo Fisher Scientific	Cat # 62209-001
Human Low Density Lipoprotein Receptor Related Protein 2 (LRP2)ELISA Kit	Bioswamp Co., Ltd	Cat # HM12145
Human Cubilin (CUBN) ELISA Kit	Bioswamp Co., Ltd	Cat # HM12367
Human Breast And Kidney Expressed Chemokine (BRAK)ELISA Kit	Bioswamp Co., Ltd	Cat # HM10258
Human Ras Homolog Gene Family, Member A (RHOA)ELISA Kit	Bioswamp Co., Ltd	Cat # HM11399
Human Cell Division Cycle Protein 42 (CDC42) ELISA Kit	Bioswamp Co., Ltd	Cat # HM12354
Human Ras Related C3 Botulinum Toxin Substrate 1 (Rac1) ELISA Kit	Bioswamp Co., Ltd	Cat # HM11359
Human Low Density Lipoprotein Receptor Related Protein 2 (LRP2)ELISA Kit	Bioswamp Co., Ltd	Cat # HM12145
Human Cubilin (CUBN) ELISA Kit	Bioswamp Co., Ltd	Cat # HM12367
Deposited data
Mass spectrometry data	https://www.iprox.org	PXD030662
Data analysis codes	https://zenodo.org/	https://doi.org/10.5281/zenodo.5642579
Software and algorithms
Xcalibur	Thermo Fisher Scientific	Cat # OPTON-30965
Proteome Discoverer Version 2.4.1.15	Thermo Fisher Scientific	N/A
R version 4.0.2	R Project	https://www.r-project.org
Ingenuine Pathway Analysis	QIAGEN Digital Insights	N/A
IMMPORT	Northrop Grumman Information Technology Health Solutions	https://www.immport.org/
UniProt	UniProt Consortium	https://www.uniprot.org/