Table 2.
TSPO cell origin in human neurological diseases
| Human disease | Microglia | Astrocytes | Neurons | Endothelial cells | Vascular smooth muscle cells | References | |
|---|---|---|---|---|---|---|---|
| Neuroinflammation | Multiple sclerosis | x | x | [7, 169] | |||
| Neurodegenerative diseases | Alzheimer’s disease | x | x | x | x | [172, 173] | |
| Dementia with Lewy-bodies | x | [173] | |||||
| Infections | HIV encephalitis | x | x | x | x | [167] | |
| Creutzfeldt-Jakob | x | [178] | |||||
| Neuropsychiatric disorders | Major depression | x | [184–186] | ||||
| Stroke | x | x | [167] | ||||
| Epilepsy | x | x | x | [188] | |||
HIV Human immunodeficiency virus