Table. 2.
Pseudo dose escalation—treatment activity vs. grading of acute hematological toxicity
| Act. | Pat. | Thrombocytopenia | Leukopenia | Anemia | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MBq | n | G0/1 | G2 | G3 | G4 | G0/1 | G2 | G3 | G4 | G0/1 | G2 | G3 | G4 |
| <15 | 5 | 4 | 0 | 1 | 0 | 5 | 0 | 0 | 0 | 5 | 0 | 0 | 0 |
| 15–19 | 10 | 10 | 0 | 0 | 0 | 9 | 1 | 0 | 0 | 10 | 0 | 0 | 0 |
| 20–24 | 6 | 6 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 5 | 1 | 0 | 0 |
| 25–29 | 6 | 6 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 6 | 0 | 0 | 0 |
| 30–34 | 2 | 1 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 |
| 35–44 | 4 | 3 | 1 | 0 | 0 | 1 | 3 | 0 | 0 | 4 | 0 | 0 | 0 |
| 45–54 | 4 | 2 | 1 | 1 | 0 | 1 | 1 | 2 | 0 | 4 | 0 | 0 | 0 |
| 55–64 | 2 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
The events highlighted in bold definded the end-of-escalation. Thus, they are no typo but have significance as eye-catchers