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. 2021 Aug 18;49(1):125–136. doi: 10.1007/s00259-021-05495-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Brain, b metabolite-corrected plasma and c olfactory bulb time–activity curves of (S)-[¹⁸F]GE387 with and without pre-treatment with 1 mg/kg of (R)-PK11195 in healthy naïve rats. Blocking effects of (R)-PK11195 are not observed to a significant extent in the healthy brain time–activity curves while plasma exposure is increased, possibly due to peripheral displacement of the radioligand