Table 1.

Parameter description and approximated experimental values for the ecology of phenotypic switching. The replication of cancer cells and the fitting of tumor growth curves with nonlinear models has been studied for decades (see e.g., (Benzekry et al. 2014) and references therein). More recently, evidence for spontaneous and stochastic phenotypic transitions in cancer cells (Neftel 2019; Gupta et al. 2011; Su et al. 2017; Goldman et al. 2015) indicates that transition rates might happen at a rate inferior to that of malignant cell replication

Parameter	Description	Experimental values	References
$r_i$	Phenotype i replication rate	0.2 $\sim$ 0.8 days${}^{-1}$	Benzekry et al. (2014) and refs. therein
$w_{\mathit{ij}}$	Rate of phenotypic transition $i\to j$	(0.01 $\sim$ 0.5)$\times r_i$ days${}^{-1}$	(Gupta et al. 2011; Goldman et al. 2015)
K	Carrying capacity of the cancerous tissue	$2\times {10}^9$ $\sim$ $4\times {10}^{10}$	(Kuznetsov et al. 1994; Wilkie and Hahnfeldt 2013)