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. 2021 Nov 25;74(1):38–48. doi: 10.1002/art.41948

Figure 4.

Figure 4

Sputum IgA anti‐CCP and NET remnant levels. A–C, Correlations between levels of sputum IgA anti‐CCP and levels of sputum NET remnants, measured as DNA–neutrophil elastase (DNA–NE) (A), DNA–MPO (B), and DNA–Cit‐H3 (C) in at‐risk subjects (n = 33). Correlations were calculated using Spearman’s correlation. D, Sputum DNA–Cit‐H3 levels in controls (n = 8), at‐risk subjects (n = 33), and RA patients (n = 7). E, Sputum DNA–Cit‐H3 levels in at‐risk subjects positive for sputum IgA anti‐CCP (n = 6) and those negative for sputum IgA anti‐CCP (n = 27). Median levels were compared between groups using Wilcoxon’s rank sum test. Open circles represent subjects negative for serum anti‐CCP3.1, and solid circles represent subjects positive for serum anti‐CCP3.1. See Figure 1 for definitions.