The association of single (green) and mixed (red) CVD profile groups with global cognitive decline compared to the reference group (black). The model also included terms for age, sex, education, time (years before death), AD-Reagan diagnosis, hippocampal sclerosis, TDP43, Lewy bodies, and their interactions with time. Unstandardized beta coefficients and 95% confidence intervals are provided with significance represented by the solid line for terms of interest; all lines display 95% confidence intervals around point estimates.