Table 3.
Associations between cerebrovascular disease profiles and declines in global cognition
| Global Cognition unstandardized beta coefficient of interaction of profile group with time (95% CI) |
||
|---|---|---|
| Single CVD profiles | Cerebral Amyloid Angiopathy (CAA) | −0.02 (−0.020,−0.019) |
| GROSS infarcts | −0.01 (−0.010,−0.009) | |
| Atherosclerosis (ATH) | −0.003 (−0.003,−0.002) | |
| Arteriolosclerosis (ART) | 0.006 (0.005,0.006) | |
| MICRO infarcts | 0.03 (0.02,0.03) | |
| Specific mixed CVD profiles | ATH+ART+GROSS | −0.05 (−0.050,−0.049) |
| ATH+ART | −0.04 (−0.040,−0.039) | |
| ART+CAA | −0.02 (−0.020,−0.019) | |
| ATH+ART+GROSS+MICRO | −0.04 (−0.040,−0.039) | |
| GROSS+MICRO | −0.005 (−0.005,−0.004) | |
| CAA+GROSS | −0.005 (−0.005,−0.004) | |
| CAA+MICRO | −0.01 (−0.010,−0.009) | |
| ATH+CAA | 0.007 (0.006,0.007) | |
| ATH+GROSS | −0.05 (−0.051,−0.048) | |
| CAA+GROSS+MICRO | −0.007 (−0.007,−0.006) | |
| Aggregated less common mixed CVD profiles | ART+any tissue damage combination | −0.03 (−0.030,−0.029) |
| ALL VESSEL only, +GROSS or +GROSS+MICRO | −0.07 (−0.07,−0.06) | |
| ATH+CAA+any tissue damage combination | −0.06 (−0.06,−0.05) | |
| ATH+MICRO with or w/o GROSS | −0.03 (−0.030,−0.029) | |
| ART+CAA+any tissue damage combination | −0.03 (−0.030,0.029) | |
| MICRO+ART+ATH alone or +CAA | −0.02 (−0.020,−0.019) |
NOTE: Specific mixed CVD profiles listed in order of descending sample size. The model included terms for each of the 21 profiles listed in the table and their interactions with time (years before death), adjusting for age, sex, education, NIA-Reagan AD diagnosis, hippocampal sclerosis, TDP-43, neocortical Lewy bodies and their interactions with time. Bolded entries signify significance based on 95% confidence intervals (CI) and p-values≤0.05.