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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Nat Chem Biol. 2021 Dec 21;18(1):8–17. doi: 10.1038/s41589-021-00903-6

Figure 1:

Figure 1:

Cells use O-GlcNAc modifications to sense metabolites resulting from altered nutrient or stress levels, a process that alters protein behaviors and can lead to disease. a) Nutrient flux through the through the hexosamine biosynthetic pathway creates UDP-GlcNAc, which is dynamically cycled onto proteins as O-GlcNAcylation by OGT and OGA. b) O-GlcNAc events regulate diverse cellular functions depending on the biological context and the type of protein that is modified. c) Aberrant O-GlcNAcylation is observed in numerous diseases that display altered hexosamine biosynthetic pathway flux.