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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Nat Chem Biol. 2021 Dec 21;18(1):8–17. doi: 10.1038/s41589-021-00903-6

Figure 5:

Figure 5:

O-GlcNAc dynamics play extensive roles in epigenetic regulation, development, and cancer. The Hexosamine Biosynthetic Pathway acts at the macronutrient level to produce UDP-GlcNAc. Nucleocytoplasmic OGT modifies transcription factors, chromatin remodeling proteins, RNA polymerase II, and splicing factors for extensive nutrient/stress-responsive epigenetic events. In development, stem cells use these programs to differentiate. Numerous cancers harness enhanced HBP flux to activate growth, survival, and metastatic programs through balancing differentiation and de-differentiation to cancer stem cells.