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. 2021 Dec 23;16:8279–8303. doi: 10.2147/IJN.S340180

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© 2021 Sun et al.

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The mortality of acute toxicity (n=10). The healthy ICR mice were assigned randomly into three groups, including (A) Free OXA group, (B) L-OXA group and (C) ES-SSL-OXA group. OXA group received a dose of 10.0, 12.0, 14.0, 16.0, 18.0 or 20.0 mg/kg. L-OXA group received a dose of 10.0, 13.0, 16.0, 19.0 or 22.0 mg/kg. ES-SSL-OXA group received a dose of 10.0, 13.0, 16.0, 19.0, 22.0 or 25.0 mg/kg. The mortality was measured till 14 days. **p < 0.01, ***p < 0.001 compared with the Free OXA group; ^##p < 0.01, ^###p < 0.001 compared with L-OXA group.