Table 4.

Plasma Concentration-Time Data (n=3)

Time (h)	Free OXA (µg/mL)	L-OXA (µg/mL)	ES-SSL-OXA (µg/mL)
0.08	28.59 ± 0.92	35.26 ± 0.50***	41.51 ± 0.77***###
0.17	25.03 ± 0.32	29.03 ± 1.35**	40.03 ± 0.17***###
0.25	10.46 ± 0.37	17.43 ± 0.44***	30.08 ± 0.65***###
0.50	4.49 ± 0.35	11.68 ± 0.06***	18.48 ± 0.22***###
1	3.20 ± 0.10	7.90 ± 0.33***	11.42 ± 0.94***###
2	2.86 ± 0.24	5.31 ± 0.27***	7.85 ± 0.14***###
4	1.99 ± 0.12	2.86 ± 0.33*	5.71 ± 0.40***###
6	1.50 ± 0.70	2.69 ± 0.10*	5.02 ± 0.15***##
8	0.64 ± 0.11	1.08 ± 0.30	3.90 ± 0.23***###
12	ND	1.00 ± 0.05	2.18 ± 0.24###
24	ND	0.31 ± 0.10	1.20 ± 0.07###
36	ND	ND	1.08 ± 0.11
48	ND	ND	0.44 ± 0.06

Notes: *p < 0.05, **p < 0.01, ***p < 0.001 compared with the Free OXA group; ^##p < 0.01, ^###p < 0.001 compared with L-OXA group.