Table 5.
Pharmacokinetic Parameters of OXA Formulations (n=3)
| Parameter | Unit | Free OXA | L-OXA | ES-SSL-OXA |
|---|---|---|---|---|
| t1/2α | H | 0.215 ± 0.077 | 0.210 ± 0.039 | 0.102 ± 0.015 |
| t1/2β | H | 3.214 ± 0.420 | 3.849 ± 0.460 | 6.246 ± 0.952**# |
| CL | L/h/kg | 0.332 ± 0.090 | 0.184 ± 0.016* | 0.082 ± 0.011** |
| AUC(0-t) | μg/L*h | 21.182 ± 3.520 | 48.966 ± 2.690*** | 112.329 ± 4.983***### |
| AUC(0-∞) | μg/L*h | 30.127 ± 3.690 | 54.341 ± 3.450*** | 122.191 ± 3.698***### |
| K10 | 1/h | 1.319 ± 0.250 | 0.561 ± 0.026** | 0.463 ± 0.023** |
| K12 | 1/h | 5.632 ± 0.360 | 2.958 ± 0.340*** | 2.873 ± 0.315*** |
| K21 | 1/h | 0.828 ± 0.070 | 1.055 ± 0.056* | 0.669 ± 0.069## |
| MRT(0-t) | H | 2.535 ± 0.520 | 5.368 ± 0.524** | 13.322 ± 1.023***### |
| MRT(0-∞) | H | 4.319 ± 0.130 | 7.259 ± 0.982** | 18.366 ± 0.856***### |
| T1/2z | H | 4.995 ± 0.360 | 7.174 ± 0.693* | 14.917 ± 0.964***### |
| Tmax | H | 0.250 ± 0.015 | 0.250 ± 0.015 | 0.250 ± 0.038 |
| CLz | L/h/kg | 0.351 ± 0.013 | 0.202 ± 0.013 | 0.090 ± 0.010 |
| Cmax | mg/L | 10.650 ± 0.920 | 17.260 ± 0.500*** | 21.470 ± 0.770***## |
Notes: *p < 0.05, **p < 0.01, ***p < 0.001 compared with the Free OXA group; #p < 0.05, ##p < 0.01, ###p < 0.001 compared with L-OXA group.