Table 6.
Biodistribution of OXA in Major Organs (n=3)
| Time (h) | Heart | Liver | ||||
|---|---|---|---|---|---|---|
| Free OXA (µg/g) | L-OXA (µg/g) | ES-SSL-OXA (µg/g) | Free OXA (µg/g) | L-OXA (µg/g) | ES-SSL-OXA (µg/g) | |
| 0.5 | 8.59 ± 0.06 | 9.23 ± 1.16 | 11.31 ± 0.63*# | 14.00 ± 0.30 | 20.62 ± 0.94*** | 24.94 ± 0.44***### |
| 1 | 10.27 ± 0.44 | 12.59 ± 0.18** | 10.61 ± 0.69## | 12.49 ± 0.56 | 21.58 ± 0.92*** | 23.10 ± 0.38*** |
| 2 | 6.79 ± 0.40 | 9.05 ± 0.87* | 8.97 ± 0.61* | 12.50 ± 0.58 | 20.15 ± 0.15*** | 24.08 ± 1.03***## |
| 4 | 5.55 ± 0.45 | 8.15 ± 0.24** | 9.77 ± 0.56***# | 10.91 ± 1.56 | 17.93 ± 1.77** | 23.17 ± 0.34***# |
| 6 | 4.22 ± 0.14 | 8.33 ± 0.40*** | 8.91 ± 0.56*** | 8.87 ± 0.40 | 16.62 ± 2.31** | 22.36 ± 1.26***# |
| 8 | 3.26 ± 0.34 | 4.56 ± 0.30** | 5.38 ± 0.27***# | 7.06 ± 0.44 | 14.00 ± 1.16*** | 20.92 ± 0.92***### |
| 12 | ND | 4.80 ± 0.20 | 4.71 ± 0.54 | ND | 12.67 ± 0.65 | 19.91 ± 1.29### |
| 24 | ND | 3.27 ± 0.20 | 3.72 ± 0.22 | ND | 9.41 ± 0.69 | 14.92 ± 0.90### |
| 36 | ND | ND | 3.75 ± 0.17 | ND | ND | 8.00 ± 0.66 |
| 48 | ND | ND | ND | ND | ND | 3.49 ± 0.60 |
| Time (h) | Spleen | Lungs | ||||
|
Free OXA (µg/g) |
L-OXA (µg/g) |
ES-SSL-OXA (µg/g) |
Free OXA (µg/g) |
L-OXA (µg/g) |
ES-SSL-OXA (µg/g) |
|
| 0.5 | 14.27 ± 0.44 | 14.39 ± 0.24 | 16.71 ± 0.69**## | 4.60 ± 0.13 | 6.14 ± 0.90 | 8.54 ± 1.29** |
| 1 | 13.40 ± 0.80 | 15.04 ± 0.61 | 21.58 ± 1.53***### | 3.70 ± 0.22 | 4.02 ± 0.89 | 5.05 ± 0.82 |
| 2 | 13.21 ± 0.22 | 14.41 ± 0.46 | 18.42 ± 1.09***## | 4.35 ± 0.63 | 4.28 ± 0.38 | 4.80 ± 0.47 |
| 4 | 10.35 ± 1.53 | 15.23 ± 2.08* | 17.37 ± 1.31** | 4.98 ± 0.18 | 4.81 ± 0.20 | 5.56 ± 0.51 |
| 6 | 10.56 ± 0.56 | 11.19 ± 0.27 | 13.57 ± 1.08**# | 4.54 ± 0.90 | 5.71 ± 1.04 | 6.47 ± 0.53 |
| 8 | 4.81 ± 0.33 | 11.07 ± .63*** | 11.84 ± 1.19*** | 3.94 ± 0.12 | 3.63 ± 0.02 | 4.72 ± 0.44*## |
| 12 | ND | 8.52 ± 0.29 | 9.73 ± 1.25 | ND | 2.56 ± 0.09 | 4.66 ± 0.69## |
| 24 | ND | 4.46 ± 0.21 | 7.46 ± 1.82# | ND | 1.47 ± 0.67 | 4.61 ± 0.61### |
| 36 | ND | ND | 6.80 ± 1.06 | ND | ND | ND |
| 48 | ND | ND | 5.13 ± 0.49 | ND | ND | ND |
| Time (h) | Kidneys | |||||
|
Free OXA (µg/g) |
L-OXA (µg/g) |
ES-SSL-OXA (µg/g) |
||||
| 0.5 | 8.73 ± 0.45 | 5.52 ± 0.31*** | 5.20 ± 0.75*** | |||
| 1 | 4.02 ± 0.61 | 4.97 ± 0.44 | 8.37 ± 0.63***### | |||
| 2 | 2.85 ± 0.27 | 4.63 ± 0.22* | 7.66 ± 0.78***### | |||
| 4 | 2.36 ± 0.70 | 9.50 ± 0.86*** | 6.93 ± 0.21***## | |||
| 6 | 2.84 ± 0.25 | 6.88 ± 0.72*** | 4.47 ± 0.45*## | |||
| 8 | 2.65 ± 0.12 | 5.90 ± 1.31* | 5.39 ± 0.71* | |||
| 12 | ND | 5.96 ± 0.97 | 5.50 ± 0.22 | |||
| 24 | ND | 5.73 ± 1.04 | 6.63 ± 0.24 | |||
| 36 | ND | ND | 3.73 ± 0.10 | |||
| 48 | ND | ND | 2.36 ± 0.37 | |||
Notes: *p < 0.05, **p < 0.01, ***p < 0.001 compared to the Free OXA group; #p < 0.05, ##p < 0.01, ###p < 0.001 compared to L-OXA group.