Table 7.

Pharmacokinetic Parameters of OXA Formulations in Major Organs (n=3)

Parameter	Heart			Liver
	Free OXA	L-OXA	ES-SSL-OXA	Free OXA	L-OXA	ES-SSL-OXA
AUC(0-t) (µg/g*h)	48.080 ± 1.690	135.950 ± 5.210***	232.360 ± 6.390***###	87.870 ± 1.360	333.570 ± 5.960***	705.590 ± 3.640***###
AUC(0-∞) (µg/g*h)	68.591 ± 5.210	293.675 ± 10.020***	461.598 ± 5.690***###	161.538 ± 3.960	666.104 ± 6.960***	775.580 ± 9.360***###
MRT(h)	5.574 ± 0.980	30.028 ± 1.980***	40.477 ± 2.130***##	9.330 ± 1.020	21.811 ± 2.630***	39.052 ± 1.650***###
Parameter	Spleen			Lungs
	Free OXA	L-OXA	ES-SSL-OXA	Free OXA	L-OXA	ES-SSL-OXA
AUC(0-t) (µg/g*h)	118.170 ± 4.560	226.460 ± 7.220***	433.260 ± 9.630***###	34.130 ± 1.960	118.170 ± 9.540***	146.260 ± 6.950***##
AUC(0-∞) (µg/g*h)	128.580 ± 9.360	337.357 ± 9.410***	693.269 ± 9.320***###	106.955 ± 9.140	122.996 ± 8.430	146.267 ± 8.410**#
MRT(h)	5.990 ± 0.230	18.686 ± 1.560**	46.804 ± 5.210***###	17.707 ± 1.990	21.415 ± 1.660	36.554 ± 3.210***###
Parameter	Kidneys
	Free OXA	L-OXA	ES-SSL-OXA
AUC(0-t) (µg/g*h)	27.380 ± 1.870	143.460 ± 9.730***	231.830 ± 6.410***###
AUC(0-∞) (µg/g*h)	69.442 ± 5.640	255.439 ± 6.490***	447.785 ± 8.580***###
MRT(h)	16.594 ± 2.220	20.515 ± 2.120	47.258 ± 4.410***###

Notes: **p < 0.01, ***p < 0.001 compared to the Free OXA group; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 compared to L-OXA group.