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The regulatory effect of CLZ on PI3K-Akt-FOXO1/GSK3β signaling. (A) PI3K (H = 23.66, p < 0.0001); (B) the ratio of p-Akt/Akt (H = 22.42, p = 0.0002); (C) the ratio of p-GSK3β/GSK3β (H = 24.64, p < 0.0001) (D) FOXO1 in cytoplasm (H = 6.519, p = 0.1636); (E) FOXO1 in nucleus (H = 23.13, p < 0.0001); (F) total FOXO1 (H = 23.30. p < 0.0001).
