FIGURE 2.

Main immune modulatory molecules tested in ALS clinical trials. On the left are listed the different tested molecules with their corresponding colors. On the figure each color dot next to the different cell types shows on which cell the immune modulatory drug is supposed to have an effect. Some cell types targeted by the drugs were well studied in the literature (see Table 4), but in some cases we completed data with theoretical targets (depending on the expression of the target on specific cell types indexed with proteinatlas.org, and for which no information in the literature was found). COX-2, cyclooxygenase-2; CSF1R, colony stimulating factor 1 receptor; IL-1R1, interleukin 1 receptor 1; IL-2, interleukin-2; IL-6R, interleukin 6 receptor; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; NRF2, nuclear factor erythroïd-2-related factor 2; PDE, phosphodiesterase; PGE2, prostaglandin E2; PI3K, phosphoinositide 3-kinase; PPARγ, peroxisome proliferator-activated receptor gamma; ROCK, Rho-associated protein kinase; S1P, sphingosine-1-phosphate receptor; TKR, tyrosine-kinase receptor; TLR-4, Toll-like receptor 4.