FIGURE 3.

MRI images from patients with different cerebral small vessel disease scores. Zero points: This patient was a 46-year-old man with no apparent lesions on MR images. One point: This patient was a 56-year-old man. Enlarged perivascular spaces (PVS) (grade 3) could be seen in the brain cortex on T2-weighted imaging. MR images showed no other abnormality. Two points: This patient was a 72-year-old woman. MRI demonstrated a lacune in the right basal ganglia, smooth halo-like lesions near the bilateral ventricles (Fazekas 2 for periventricular WMH), confluent white matter hyperintensities (Fazekas 2 for deep WMH) in the deep lobe and enlarged PVS (grade 1) in the bilateral basal ganglia. Susceptibility-weighted imaging showed no abnormality. Three points: This patient was a 69-year-old woman. MRI showed irregular white matter lesions in the lateral ventricles extending to the white matter (Fazekas 3 for periventricular WMH), large confluent areas of WMH (Fazekas 3 for deep WMH) in the center of the bilateral semioval and enlarged PVS (grade 3). Four points: This patient was a 77-year-old man. There were patchy, irregular white matter lesions extending to the white matter in the lateral ventricle (Fazekas 3 for periventricular WMH), fused WMH (Fazekas 3 for deep WMH), and 2 lacunes in the parietal lobe, enlarged PVS (grade 2) in the bilateral basal ganglia, and cerebral microbleeds at the level of the bilateral ventricles. All 4 MRI markers appeared in the images from this patient.