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. 2021 Dec 14;11:761169. doi: 10.3389/fonc.2021.761169

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Copyright © 2021 Zhylka, Sollmann, Kofler, Radwan, De Luca, Gempt, Wiestler, Menze, Krieg, Zimmer, Kirschke, Sunaert, Leemans and Pluim

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of reconstructions of the corticospinal tract (CST) depending on the algorithm chosen for tractography. This figure shows reconstructions of the CST within the tumor-affected and unaffected hemispheres in a subset of 10 patients from the cohort, using diffusion tensor imaging (DTI)-based tractography, constrained spherical deconvolution (CSD)-based tractography, and multi-level fiber tracking (MLFT). The tumor core is shown as a red volume, the hyperintense zone in fluid attenuated inversion recovery (FLAIR) sequences is shown as a yellow volume. While CSD-based tractography provides reconstructions comparable to DTI-based tractography, MLFT is able to improve depiction of the extent of the CST fanning of both tumor-affected and unaffected hemispheres.