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. 2021 Dec 14;11:761169. doi: 10.3389/fonc.2021.761169

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Copyright © 2021 Zhylka, Sollmann, Kofler, Radwan, De Luca, Gempt, Wiestler, Menze, Krieg, Zimmer, Kirschke, Sunaert, Leemans and Pluim

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differences between the radial extent of tumor-affected and unaffected hemispheres. This figure shows the radial extent differences in relation to combined tumor and FLAIR-hyperintense zone volumes (orange) using the mean (black dashed line) with +/- 2 standard deviation (SD, provided as σ; red dashed lines) to identify potential outliers. Circles represent data points for the corticospinal tract (CST) as derived from multi-level fiber tracking (MLFT), while + represents data points derived from constrained spherical deconvolution (CSD)-based tractography and x represents data points stemming from diffusion tensor imaging (DTI)-based tractography. The outliers with positive radial extent difference are of most interest as they show unexpected behavior with higher radial extent in the tumor-affected hemisphere.