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. 2021 Dec 14;9:744932. doi: 10.3389/fcell.2021.744932

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Copyright © 2021 Ran, Yuan, Fan, Ke, Wang, Sun and Su.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The comprehensive disease regulatory network and information decoding. (A) CSSPN. Green circle, orange rhombuses, and blue inverted triangles represent mRNAs, miRNAs, and lncRNAs respectively. The SNPs located in lncRNA, pri-/pre-miRNA, and the 3′UTR of mRNA were shown with the red circle around the mRNAs, miRNAs, and lncRNAs. The SNPs within the 3′UTR of mRNA, the seed region of mature miRNA, and the miRNA binding site on lncRNA were exhibited with green, orange, and blue dash lines respectively. The red dash line indicates the seed region of mature miRNA and 3′UTR of mRNA contain SNPs, which could affect miRNA-mRNA binding. (B) The multi-bar plot shows gene mapping and SNP mapping information pathways. The top and bottom axis represented the number of mapping genes and mapping SNPs respectively. (C) The dot plot of regulatory SNPs density and ceRNA regulation with SNP ratio. The top axis showed the density of regulatory SNPs. The percentage represented by the bottom axis reflects the proportion of ceRNA regulation with SNP in the total ceRNA regulations.