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. 2021 Dec 14;12:788442. doi: 10.3389/fmicb.2021.788442

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Copyright © 2021 Zhang, Liu, Chen, Zong, Hou, Qiu, Guo, Sun, Jiang, An and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme of synthesizing rHSA and AN NP. (A) HSA powder was dispersed in SDS and DTT, then the mixture was heated to 90°C and magnetically stirred at 180 rpm for 2 h to obtain reduced HSA (rHSA). (B) rHSA in MES buffer was magnetically stirred at 350 rpm and 25°C with AN (m/m 50:1) for 2 h to form the AN nanoparticles (AN NP).