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. 2021 Dec 14;12:788442. doi: 10.3389/fmicb.2021.788442

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Copyright © 2021 Zhang, Liu, Chen, Zong, Hou, Qiu, Guo, Sun, Jiang, An and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AN NP exhibits stronger activity against Candida albicans compared to AN. (A) Time-kill kinetics assay of Candida albicans SC5314 and 538 treated with AN or AN NP. Strains were grown in YEPD medium with a starting inoculum of 5 × 10⁵CFU/mL. *P < 0.05 (one-way analysis of variance). (B) Antifungal susceptibility testing of Candida albicans SC5314 and 538 using 8 mm disks. a, c represents, respectively 1 μg and 2 μg AN, respectively; b, d represents AN NP (containing 1 μg or 2 μg AN, respectively); e represents PBS. The size of each inhibition zone diameter is marked on the figure.