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. 2021 Dec 14;12:788442. doi: 10.3389/fmicb.2021.788442

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Copyright © 2021 Zhang, Liu, Chen, Zong, Hou, Qiu, Guo, Sun, Jiang, An and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AN NP is much more effective than AN for treating invasive candidiasis caused by C. albicans. (A) Survival curves for mice with Candida albicans treated with antifungal agents. Mice were monitored without therapy until day 6. **P < 0.005 versus the results for the control [Log-rank (Mantel–Cox) test]. (B) Fungal burdens in mice with invasive Candida albicans treated with antifungal agents. Mice were humanely euthanized 2 days after treatment; kidney samples were then collected for fungal burden analysis. Horizontal lines represent mean values, and whiskers representing standard deviations. ***P < 0.0001 versus the result for the control (one-way analysis of variance). (C) Representative H&E and PAS staining of kidneys from C. albicans SC5314-infected mice with indicated treatment at day two, post-infection. Black dotted frame indicates inflammatory cells (H&E) and hypha (PAS) in the tissues.