Table 3.
Univariable and multivariable Cox regression analysis for predictors of outcome
| All‐cause mortality | Cardiovascular mortality or transplant | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Univariable analysis | Multivariable analysis | Univariable analysis | Multivariable analysis | ||||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | ||
| Female | 0.94 (0.527–1.695) | 0.849 | 0.85 (0.409–1.784) | 0.675 | |||||
| Aetiology | Non‐syndromic | Baseline | Baseline | ||||||
| RASopathy | 1.87 (0.867–4.029) | 0.110 | 1.10 (0.534–2.272) | 0.793 | |||||
| IEM | 6.40 (3.054–13.484) | <0.001 | 4.40 (1.950–9.659) | <0.001 | 2.45 (1.088–5.521) | 0.029 | 2.19 (0.938–5.125) | 0.070 | |
| Co‐morbidities | Cardiac | 0.82 (0.406–1.645) | 0.571 | 0.81 (0.328 0 1.983) | 0.640 | ||||
| Any | 0.63 (0.345–1.140) | 0.126 | 1.29 (0.631–2.653) | 0.482 | |||||
| Family history of HCM | 0.26 (0.095–0.735) | 0.011 | 0.44 (0.155–1.280) | 0.133 | |||||
| Family history of SCD | 1.11 (0.399–3.094) | 0.840 | 1.32 (0.401–4.340) | 0.649 | |||||
| Any symptoms at baseline | 3.96 (2.011–7.805) | <0.001 | 3.26 (1.419–7.483) | 0.005 | 7.84 (2.727–22.557) | <0.001 | 19.1 (4.222–86.704) | <0.001 | |
| LVOTO | 1.49 (0.775–2.852) | 0.233 | 0.66 (0.314–1.385) | 0.272 | |||||
| RVOTO | 1.37 (0.634–2.957) | 0.424 | 2.07 (0.736–5.844) | 0.167 | |||||
| Increasing maximal wall thickness | 1.01 (0.934–1.100) | 0.742 | 0.0437 | 1.19 (1.067–1.344) | 0.002 | ||||
| Impaired systolic function | 5.43 (2.117–13.248) | <0.001 | 2.97 (1.124–7.865) | 0.028 | 1.46 (0.190–11.217) | 0.717 | |||
CI, confidence interval; HCM, hypertrophic cardiomyopathy; HR, hazard ratio; IEM, inborn error of metabolism; LVOTO, left ventricular outflow tract obstruction; RVOTO, right ventricular outflow tract obstruction; SCD, sudden cardiac death.