Study ID	Health‐related quality of life	Hypothyroidism	Adverse events	Thyroid volume	All‐cause mortality	Costs
Albino 2010	NR	T3, (f)T4, TSH measurements	Adverse effects were evaluated by clinical assessment, and by frequent measurements of thyroid hormone levels, goitre enlargement, compressive symptoms	Thyroid volume was measured by MRI. The thyroid limits were manually drawn, and the thyroid area was calculated by the built‐in (dedicated) software	NR	NR
Bonnema 2007	NR	T3, (f/t)T4, TSH measurements	Goitre‐related symptoms	Goitre size was estimated by MRI	NR	NR
Cubas 2009	NR	T3, (f)T4, TSH measurements	Symptoms of hyperthyroidism; enlargement of the thyroid without compressive symptoms, or moderate cervical pain	CT scan	death	NR
Fast 2010	NR	(f/t)T3, (f/t)T4, TSH measurements	Proportion of participants experiencing adverse effects, such as goitre‐related pressure symptoms (i.e. cervical obstructive symptoms)	In 70 participants, a planimetric ultrasonic scanning procedure was performed; in the remaining 20 participants, retroclavicular extension of the gland impeded an accurate ultrasonic assessment – in these participants, planimetric measurements were based on MRI	NR	NR
Fast 2014	Thyroid disease‐specific questionnaire ThyPRO	(f/t)T3, (f/t)T4, TSH measurements	Participants were continuously monitored for adverse events (AEs), which were coded using the Medical Dictionary for Regulatory Activities (MedDRA) v 10.0 or higher	CT scan	NR	NR
Nielsen 2006	NR	(f/t)T3, (f/t)T4, TSH measurements	ND	Ultrasonography	NR	NR
CT: computed tomography; ND: not defined;NR: not reported; MRI: magnetic resonance imaging; (f/t)T3: (free) triiodothyronine; (f/t)T4: (free/total) thyroxine; THyPRO: thyroid‐related patient‐reported outcomes; TSH: thyroid‐stimulating hormone.